Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00359734" target="_blank" >RIV/67985823:_____/11:00359734 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1476-5381.2010.01081.x" target="_blank" >http://dx.doi.org/10.1111/j.1476-5381.2010.01081.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1476-5381.2010.01081.x" target="_blank" >10.1111/j.1476-5381.2010.01081.x</a>

Result language
angličtina
Original language name
Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy
Original language description
Our findings suggest the existence of a low-affinity agonist-receptor conformation complexed with GDP-liganded G-protein. Also the negative cooperativity between GDP and agonist binding at the receptor/G-protein complex determines agonist efficacy. GDP binding reveals differences in action of agonists versus inverse agonists as well as differences in activation of Gi/o versus Gs/olf G-proteins that are not identified by conventional GTPalphaS binding
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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