Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00365728" target="_blank" >RIV/67985823:_____/11:00365728 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/nature10490" target="_blank" >http://dx.doi.org/10.1038/nature10490</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nature10490" target="_blank" >10.1038/nature10490</a>

Result language

angličtina

Original language name

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

Original language description

Left ventricular mass (LVM) is a highly heritable trait and an independent risk factor for all-cause mortality. We identified mutation in endonuclease G (Endog) that is associated with increased LVM and impaired cardiac function. Our study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

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Volume of the periodical

478

Issue of the periodical within the volume

7367

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

114-118

UT code for WoS article

000295575400045

EID of the result in the Scopus database

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