Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00370173" target="_blank" >RIV/67985823:_____/11:00370173 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.biocel.2010.05.003" target="_blank" >http://dx.doi.org/10.1016/j.biocel.2010.05.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2010.05.003" target="_blank" >10.1016/j.biocel.2010.05.003</a>

Result language
angličtina
Original language name
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
Original language description
In this review authors posit following hypothesis: Independently of whether malignant tumors are initiated by a fundamental reprogramming of gene expression or seeded by stem cells, waves of gene expression that promote metabolic changes occur during carcinogenesis, beginning with oncogene-mediated changes, followed by hypoxia-induced factor (HIF)-mediated gene expression, both resulting in the highly glycolytic Warburg phenotype and suppression of mitochondrial biogenesis
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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