Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00376806" target="_blank" >RIV/67985823:_____/12:00376806 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/j.1748-1716.2011.02395.x" target="_blank" >http://dx.doi.org/10.1111/j.1748-1716.2011.02395.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1748-1716.2011.02395.x" target="_blank" >10.1111/j.1748-1716.2011.02395.x</a>

Result language

angličtina

Original language name

Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats

Original language description

The role of endothelin-1 in the development or the maintenance of salt hypertension induced in young (4-week-old) or adult (12-week-old) Dahl rats was compared. Acute ET(A) receptor blockade lowered BP in both age groups of salt hypertensive Dahl rats more than in rats fed a low-salt diet (but without any age-dependent difference). Chronic ET(A) receptor blockade strongly attenuated the development of salt hypertension and cardiac hypertrophy in adult rats, but it had no significant effects on salt hypertension in young animals. Pronounced BP reduction induced in adult salt hypertensive rats by chronic ambrisentan treatment was attributed to attenuated sympathetic BP component, without changes in nitric oxide (NO)-dependent BP regulation. Thus ET(A) receptor-mediated ET-1 effects play an important role in salt hypertension of adult but not young Dahl rats

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Physiologica

ISSN

1748-1708

e-ISSN

—

Volume of the periodical

205

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

124-132

UT code for WoS article

000302154300013

EID of the result in the Scopus database

—