N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00385447" target="_blank" >RIV/67985823:_____/12:00385447 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1460-9568.2012.08234.x" target="_blank" >http://dx.doi.org/10.1111/j.1460-9568.2012.08234.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1460-9568.2012.08234.x" target="_blank" >10.1111/j.1460-9568.2012.08234.x</a>
Alternative languages
Result language
angličtina
Original language name
N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses
Original language description
Using a highly selective neuronal NO synthase (nNOS) inhibitor, Nw-propyl-L-arginine (L-NPA), we investigated the effects of nNOS in the development of seizures and neurobiological changes, during status epilepticus (SE) and the early latent period, using a kainic acid (KA)-induced seizure model in C57BL/6J mice. The results suggest that nNOS plays a contributory role in seizure severity during SE and is important for neurobiological changes, associated with the development of chronic epilepsy, in the early latent period of epileptogenesis and may represent a novel target for pharmacological modulation in the treatment of epilepsy
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F10%2F0999" target="_blank" >GAP303/10/0999: The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neuroscience
ISSN
0953-816X
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
3194-3203
UT code for WoS article
000310683800006
EID of the result in the Scopus database
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