Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00386496" target="_blank" >RIV/67985823:_____/12:00386496 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/jnc.12002" target="_blank" >http://dx.doi.org/10.1111/jnc.12002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jnc.12002" target="_blank" >10.1111/jnc.12002</a>

Result language
angličtina
Original language name
Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors
Original language description
Using chimeric and mutated GluN1 subunits expressed in heterologous cells, we identified a single amino acid residue within the fourth membrane domain (M4) of GluN1 subunit, L830, that regulates the surface number of NMDA receptors. Our experiments showthat this residue is not critical for the interaction between GluN1 and GluN2 subunits or for the formation of functional receptors, but rather that it regulates the forward trafficking of the NMDA receptors
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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