RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00391765" target="_blank" >RIV/67985823:_____/13:00391765 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/nar/gks1353" target="_blank" >http://dx.doi.org/10.1093/nar/gks1353</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gks1353" target="_blank" >10.1093/nar/gks1353</a>
Alternative languages
Result language
angličtina
Original language name
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
Original language description
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. Have isolated three proteins that repress ADAR2-mediated RNA editing. RPS14, SFRS9 and DDX 15 interact with RNA. Overexpressionor depletion of these proteins can decrease or increase editing levels by 15 %, thus allowing a modulation of RNA editing up to 30 %. Expression of the three factors decreases during mouse brain development. Moreover, expression levels of SFRS9 and DDX15respond strongly to neuronal stimulation or repression
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
2581-2593
UT code for WoS article
000318062000047
EID of the result in the Scopus database
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