Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00393015" target="_blank" >RIV/67985823:_____/13:00393015 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neuropharm.2012.11.014" target="_blank" >http://dx.doi.org/10.1016/j.neuropharm.2012.11.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuropharm.2012.11.014" target="_blank" >10.1016/j.neuropharm.2012.11.014</a>

Result language
angličtina
Original language name
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42)
Original language description
We investigated immediate and prolonged in vitro effects of non-aggregated ABeta1-42 on coupling of individual muscarinic receptor subtypes expressed in CHO(Chinese hamster ovary) cells and their underlying mechanisms. Our results provide strong evidencethat the initial injurious effects of ABETA1-42 on M1 muscarinic receptor-mediated transmissions is due to compromised coupling of the receptor with Gq/11 G-protein
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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