On homology modeling of the M-2 muscarinic acetylcholine receptor subtype

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00398286" target="_blank" >RIV/67985823:_____/13:00398286 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10822-013-9660-8" target="_blank" >http://dx.doi.org/10.1007/s10822-013-9660-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10822-013-9660-8" target="_blank" >10.1007/s10822-013-9660-8</a>

Result language
angličtina
Original language name
On homology modeling of the M-2 muscarinic acetylcholine receptor subtype
Original language description
Twelve homology models of the human M2 muscarinic receptor using different sets templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON). Data document a key role of the template in homology modelling. Although estimation of relative binding energies distinguishes between relatively good and bad models it does not indicate the best one. On the other hand, visual inspection of the models for known features and knowledge-based analysis of in intramolecular interactions allows an experimenter to select overall best models manually
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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