Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00398357" target="_blank" >RIV/67985823:_____/13:00398357 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0077786" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0077786</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0077786" target="_blank" >10.1371/journal.pone.0077786</a>

Result language
angličtina
Original language name
Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2
Original language description
Comparing UCP1 and UCP2 reconstituted in planar lipid bilayers, we demonstrated that 4-hydroxy-2-nonenal (HNE) does not directly activate either UCP1 or UCP2. However, HNE strongly potentiated the membrane conductance increase (Gm) mediated by differentlong-chain fatty acids in UCP-containing and in UCP-free membranes and this suggest the involvement of both lipid-mediated and protein-mediated mechanisms with FA playing the central role
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
<a href="/en/project/GAP302%2F10%2F0346" target="_blank" >GAP302/10/0346: 3D imaging of mitochondrial network and ultrastructure in relation to bioenergetics, hypoxia, and diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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