Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00428039" target="_blank" >RIV/67985823:_____/14:00428039 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?

Original language description

Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Here we give an overview of some GOF mutants in polymodal ion channels specifically involved in transduction of painful stimuli ? TRPV1 and TRPA1, which are scrutinized by scientists due to their important role in development of some pathological pain states

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

Suppl.1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

"S205"-"S213"

UT code for WoS article

000332073100017

EID of the result in the Scopus database

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