Natural variation of histone modification and its impact on gene expression in the rat genome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00429012" target="_blank" >RIV/67985823:_____/14:00429012 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1101/gr.169029.113" target="_blank" >http://dx.doi.org/10.1101/gr.169029.113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1101/gr.169029.113" target="_blank" >10.1101/gr.169029.113</a>

Result language
angličtina
Original language name
Natural variation of histone modification and its impact on gene expression in the rat genome
Original language description
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. The integrated analysis of DNA variation together with histone methylation andgene expression levels showed that histone QTLs are an important predictor of gene expression and that a joint analysis significantly enhanced the prediction of gene expression traits (eQTLs). Our data suggest that genetic variation has widespread impacton histone trimethylation marks that may help to uncover novel genotype-phenotype relationships
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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