Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435667" target="_blank" >RIV/67985823:_____/14:00435667 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s11745-014-3948-x" target="_blank" >http://dx.doi.org/10.1007/s11745-014-3948-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11745-014-3948-x" target="_blank" >10.1007/s11745-014-3948-x</a>

Result language

angličtina

Original language name

Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Original language description

We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activatedreceptor (PPAR)-? target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/GA13-00871S" target="_blank" >GA13-00871S: Enhancing energy expenditure in white adipose tissue by combination treatments using n-3 fatty acids, resveratrol and calorie restriction</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lipids

ISSN

0024-4201

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1081-1089

UT code for WoS article

000344151800001

EID of the result in the Scopus database

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