TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435671" target="_blank" >RIV/67985823:_____/14:00435671 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1744-8069-10-67" target="_blank" >http://dx.doi.org/10.1186/1744-8069-10-67</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1744-8069-10-67" target="_blank" >10.1186/1744-8069-10-67</a>

Result language

angličtina

Original language name

TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Original language description

Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear. Transient receptor potential vanilloid 1 (TRPV1) receptors are involved in nociceptive signalingin various hypersensitive states. Here we have investigated the contribution of TRPV1 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of hypersensitivity to thermal and mechanical stimuli following surgical incision. A rat plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the TRPV1 receptor antagonist SB366791 was investigated 1) by intrathecal injection 15 min beforeincision and 2) intradermal injection before (30 min) and immediately after the surgery. Vehicle-injected rats and na?ve animals treated identically were used as controls

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Pain

ISSN

1744-8069

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

2014

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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