Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435721" target="_blank" >RIV/67985823:_____/14:00435721 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.foodres.2014.03.050" target="_blank" >http://dx.doi.org/10.1016/j.foodres.2014.03.050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.foodres.2014.03.050" target="_blank" >10.1016/j.foodres.2014.03.050</a>

Result language

angličtina

Original language name

Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

Original language description

We performed a systematic phenotypic evaluation of the effects of selected polyphenols (Epigallocatechin-gallate, quercetin, and resveratrol) in wildtype C57BL/6JOlaHsd mice fed high fat diet for 12 weeks. Results showed that these polyphenols were present in circulation, but did not induce beneficial health effects as analyzed by oral glucose tolerance testing or serum adipokines and CVD-markers such as vascular adhesion molecules. Remarkably, transcriptomics of white adipose tissue showed overlappingsets of significantly differential transcript levels between these polyphenols; AMPK and Notch signaling were affected by these polyphenols. However, mitochondrial processes and mitochondrial density in this tissue did not differ between the polyphenols,which suggested that there was no direct effect on adipose tissue

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Food Research International

ISSN

0963-9969

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

part A

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

95-102

UT code for WoS article

000347756000013

EID of the result in the Scopus database

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