Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00436413" target="_blank" >RIV/67985823:_____/14:00436413 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00418-014-1247-5" target="_blank" >http://dx.doi.org/10.1007/s00418-014-1247-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-014-1247-5" target="_blank" >10.1007/s00418-014-1247-5</a>
Alternative languages
Result language
angličtina
Original language name
Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status
Original language description
We studied the effect of regeneration, altered innervation and thyroid hormone levels on fiber type transitions in slow soleus (SOL) muscles grafted (GRAFT) into host extensor digitorum longus (EDLh) muscles of euthyroid (EU), hyperthyroid (HT) and hypothyroid (HY) Lewis strain rats. SOL muscles were excised from 3- to 4-week-old inbred Lewis rats and intramuscularly transplanted into EDLh muscles of 2-month-old female rats of the same strain. The transition towards fast muscle phenotype was more pronounced in HT status, where the fastest type 2B fibers predominated. On the contrary, in HY status, the slow to fast transformation was less pronounced, as GRAFT contained less type 2B and 2X but more type 2A and 1 fibers. We conclude that the type of innervation is the crucial factor for the slow to fast fiber type transitions in GRAFT, but the extent of muscle transformation is further modulated by altered TH status
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histochemistry and Cell Biology
ISSN
0948-6143
e-ISSN
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Volume of the periodical
142
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
677-684
UT code for WoS article
000346930200007
EID of the result in the Scopus database
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