Vcx1 and ESCRT components regulate intracellular pH homeostasis in the response of yeast cells to calcium stress

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00444132" target="_blank" >RIV/67985823:_____/15:00444132 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/femsyr/fov007" target="_blank" >http://dx.doi.org/10.1093/femsyr/fov007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femsyr/fov007" target="_blank" >10.1093/femsyr/fov007</a>

Result language
angličtina
Original language name
Vcx1 and ESCRT components regulate intracellular pH homeostasis in the response of yeast cells to calcium stress
Original language description
In this work we focused on intracellular pH (pHin) homeostasis of ESCRT mutants. None of them exhibited an altered pHin level compared to the wild type under standard growth conditions. Nevertheless, 60 min of CaCl2 treatment resulted in a more significant drop in pHin levels in these mutants than in the wild type, suggesting that pHin homeostasis is affected in ESCRT mutants upon the addition of calcium. Similarly, CaCl2 treatment caused a bigger pHin decrease in cells lacking the vacuolar Ca2+/H+ antiporter Vcx1 which indicates a role for this protein in the maintenance of proper pHin homeostasis when cells need to cope with a high CaCl2 concentration in media
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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