Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00454395" target="_blank" >RIV/67985823:_____/15:00454395 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10863-015-9628-6" target="_blank" >http://dx.doi.org/10.1007/s10863-015-9628-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10863-015-9628-6" target="_blank" >10.1007/s10863-015-9628-6</a>

Result language
angličtina
Original language name
Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells
Original language description
Cancer cell bioenergetics, maintaining mixed aerobic glycolysis and oxidative phosphorylation, is not fully elucidated. We have studied energy metabolism of hepatocellular carcinoma, HepG2 cells in three different cultivation regimes, i.e. in glycolytic(5mM or 25mM glucose) and aglycemic (no glucose, galactose supplementation) conditions. We found that conventional hypoxia mediated suppression of respiration was prevented in aglycemia. We described it as a non-canonical hypoxic regulation. Such state of energy metabolism may explain distinct tumor sensitivity to chemotherapy and other pharmacological interventions
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)