Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458422" target="_blank" >RIV/67985823:_____/16:00458422 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10321667
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbrc.2015.12.055" target="_blank" >http://dx.doi.org/10.1016/j.bbrc.2015.12.055</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbrc.2015.12.055" target="_blank" >10.1016/j.bbrc.2015.12.055</a>
Alternative languages
Result language
angličtina
Original language name
Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids
Original language description
The fractionation and metabolipidomic analysis were used to identify cells producing lipid mediators in epididymal WAT of mice fed for 5 weeks obesogenic high-fat diet (lipid content 35% wt/wt), which was supplemented or not by omega-3 PUFA (4.3 mg eicosapentaenoic acid and 14.7 mg docosahexaenoic acid per g of diet). Our results demonstrate selective increase in levels of anti-inflammatory lipid mediators in WAT in response to omega-3, reflecting either their association with adipocytes (endocannabinoid-related N-docosahexaenoylethanolamine) or with stromal vascular cells (pro-resolving lipid mediator protectin D1). These results further document specific roles of various cell types in WAT in control of WAT inflammation and metabolism and they suggest that also other cells but ATMs are engaged in production of proresolving lipid mediators in response to omega-3 PUFA.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical and Biophysical Research Communications
ISSN
0006-291X
e-ISSN
—
Volume of the periodical
469
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
731-736
UT code for WoS article
000369352800062
EID of the result in the Scopus database
2-s2.0-84953635674