Allosteric Modulation of Muscarinic Receptors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458562" target="_blank" >RIV/67985823:_____/16:00458562 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_6" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-2858-3_6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_6" target="_blank" >10.1007/978-1-4939-2858-3_6</a>

Result language
angličtina
Original language name
Allosteric Modulation of Muscarinic Receptors
Original language description
Allosteric ligands modulate binding and function of muscarinic receptors in a different way than orthosteric ligands. Unlike orthosteric ligands their effects are limited by a cooperativity factor. This imparts them unique properties, including cooperativity-based selectivity, functional selectivity and restoring of physiological-like space and time pattern of signaling under pathological conditions. Therefore, allosteric modulators of muscarinic receptor are intensively studied as possible therapeutics of pathological conditions including Alzheimer’s disease and schizophrenia. Research of allosteric modulation has pioneered the way for a whole class A of G-protein coupled receptors and has had an impact beyond its own field. We review principles of allosteric modulations and their implications for proper design of binding as well as functional experiments and for proper data analysis.
Czech name
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Czech description
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Project
<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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