Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00462516" target="_blank" >RIV/67985823:_____/16:00462516 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/16:00462479 RIV/00216208:11110/16:10327339 RIV/00023761:_____/16:N0000007

Result on the web

<a href="http://dx.doi.org/10.1530/JOE-15-0519" target="_blank" >http://dx.doi.org/10.1530/JOE-15-0519</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/JOE-15-0519" target="_blank" >10.1530/JOE-15-0519</a>

Result language

angličtina

Original language name

Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats

Original language description

Anorexigenic neuropeptides produced and acting in the brain have the potential to decrease food intake and ameliorate obesity, but are ineffective after peripheral application, owing to a limited ability to cross the blood–brain barrier. We have designed lipidized analogs of prolactin-releasing peptide (PrRP), which is involved in energy balance regulation as demonstrated by obesity phenotypes of both Prrp-knockout and Prrp receptor-knockout mice. The aim of this study was to characterize the subchronic effect of a palmitoylated PrRP analog in two rat models of obesity and diabetes: diet-induced obese Sprague–Dawley rats and leptin receptor-deficient Zucker diabetic (ZDF) rats. In the rats with diet-induced obesity (DIO), a two-week intraperitoneal treatment with palmitoylated PrRP lowered food intake by 24% and body weight by 8%. This treatment also improved glucose tolerance and tended to decrease leptin levels and adipose tissue masses in a dose-dependent manner. In contrast, in ZDF rats, the same treatment with palmitoylated PrRP lowered food intake but did not significantly affect body weight or glucose tolerance, probably in consequence of severe leptin resistance due to a nonfunctional leptin receptor. Our data indicate a good efficacy of lipidized PrRP in DIO rats. Thus, the strong anorexigenic, body weight-reducing, and glucose tolerance-improving effects make palmitoylated PrRP an attractive candidate for anti-obesity treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Endocrinology

ISSN

0022-0795

e-ISSN

—

Volume of the periodical

229

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

85-96

UT code for WoS article

000378643100006

EID of the result in the Scopus database

2-s2.0-84977624840