Integration of superoxide formation and cristae morphology for mitochondrial redox signaling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00463353" target="_blank" >RIV/67985823:_____/16:00463353 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biocel.2016.09.010" target="_blank" >http://dx.doi.org/10.1016/j.biocel.2016.09.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biocel.2016.09.010" target="_blank" >10.1016/j.biocel.2016.09.010</a>

Result language

angličtina

Original language name

Integration of superoxide formation and cristae morphology for mitochondrial redox signaling

Original language description

The mitochondrial network provides the central cell’s energetic and regulatory unit, which besides ATP and metabolite production participates in cellular signaling through regulated reactive oxygen species (ROS) production and various protein/ion fluxes. The inner membrane forms extensive folds, called cristae, i.e. cavities enfolded from and situated perpendicularly to its inner boundary membrane portion, which encompasses an inner cylinder within the outer membrane tubule. Mitochondrial cristae ultramorphology reflects various metabolic, physiological or pathological states. Since the mitochondrion is typically a predominant superoxide source and generated ROS also serve for the creation of information redox signals, we review known relationships between ROS generation within the respiratory chain complexes of cristae and cristae morphology. Notably, it is emphasized that cristae shape is governed by ATP-synthase dimers, MICOS complexes, OPA1 isoforms and the umbrella of their regulation, and also dependent on local protonmotive force (electrical potential component) in cristae. Cristae are also affected by redox-sensitive kinases/phosphatases or p66SHC. ATP-synthase dimers decrease in the inflated intracristal space, diminishing pH and hypothetically having minimal superoxide formation. Matrix-released signaling superoxide/H2O2 is predominantly integrated along mitochondrial tubules, whereas the diffusion of intracristal signaling ROS species is controlled by crista junctions, the widening of which enables specific retrograde redox signaling such as during hypoxic cell adaptation. Other physiological cases of H2O2 release from the mitochondrion include the modulation of insulin release in pancreatic beta-cells, enhancement of insulin signaling in peripheral tissues, signaling by T-cell receptors, retrograde signaling during the cell cycle and cell differentiation, specifically that of adipocytes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biochemistry and Cell Biology

ISSN

1357-2725

e-ISSN

—

Volume of the periodical

80

Issue of the periodical within the volume

Nov

Country of publishing house

GB - UNITED KINGDOM

Number of pages

20

Pages from-to

31-50

UT code for WoS article

000388053400004

EID of the result in the Scopus database

2-s2.0-84988527613