Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00464970" target="_blank" >RIV/67985823:_____/16:00464970 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10327254 RIV/00023001:_____/16:00059978 RIV/75010330:_____/16:00011365
Result on the web
<a href="http://dx.doi.org/10.1253/circj.CJ-15-1309" target="_blank" >http://dx.doi.org/10.1253/circj.CJ-15-1309</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1253/circj.CJ-15-1309" target="_blank" >10.1253/circj.CJ-15-1309</a>
Alternative languages
Result language
angličtina
Original language name
Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -
Original language description
Background: The aim of our study was to investigate the relationship between the cardiac magnetic resonance (CMR)-derived native T1 relaxation time and myocardial extracellular volume (ECV) fraction and the extent of diffuse myocardial fibrosis (DMF) on targeted myocardial left ventricular (LV) biopsy. nnMethods and Results: The study population consisted of 40 patients (age 63 +/- 8 years, 65% male) undergoing valve and/or ascending aorta surgery for severe aortic stenosis (77.5%), root dilatation (7.5%) or valve regurgitation (15%). The T1 relaxation time was assessed in the basal interventricular septum pre-and 10-min post-contrast administration using the modified Look-Locker Inversion recovery sequence prior to surgery. LV myocardial biopsy specimen was obtained during surgery from the basal interventricular septal segment matched with the T1 mapping assessment. The percentage of myocardial collagen was quantified using picrosirius red staining. The average percentage of myocardial collagen was 22.0 +/- 14.8%. Both native T1 relaxation time with cutoff value >= 1,010 ms (sensitivity=90%, specificity=73%, area under the curve=0.82) and ECV with cutoff value >= 0.32 (sensitivity=80%, specificity=90%, area under the curve=0.85) showed high accuracy to identify severe (>30%) DMF. The native T1 relaxation time showed significant correlation with LV mass (P<0.01). nnConclusions: Native T1 relaxation time and ECV at 10 min after contrast administration are accurate markers of DMF.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP302%2F11%2F1308" target="_blank" >GAP302/11/1308: Epigenetic factors in myocardial morphogenesis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Circulation Journal
ISSN
1346-9843
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
5
Country of publishing house
JP - JAPAN
Number of pages
8
Pages from-to
1202-1209
UT code for WoS article
000377142700023
EID of the result in the Scopus database
2-s2.0-84964311224