Acute temperature effects on function of the chick embryonic heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00465930" target="_blank" >RIV/67985823:_____/16:00465930 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/16:10325691 RIV/00216208:11110/16:10325691
Result on the web
<a href="http://dx.doi.org/10.1111/apha.12691" target="_blank" >http://dx.doi.org/10.1111/apha.12691</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apha.12691" target="_blank" >10.1111/apha.12691</a>
Alternative languages
Result language
angličtina
Original language name
Acute temperature effects on function of the chick embryonic heart
Original language description
We analysed the effects of acute temperature change on the beating rate, conduction properties and calcium transients in the chick embryonic heart invitro and in ovo. MethodsThe effects of temperature change (34, 37 and 40 degrees C) on calcium dynamics in isolated ED4 chick hearts invitro were investigated by high-speed calcium optical imaging. For comparison and validation of invitro measurements, experiments were also performed in ovo using videomicroscopy. Artificial stimulation experiments were performed invitro and inovo to uncover conduction limits of heart segments. ResultsDecrease in temperature from 37 to 34 degrees C invitro led to a 22% drop in heart rate and unchanged amplitude of Ca2+ transients, compared to a 25% heart rate decrease in ovo. Increase in temperature from 37 to 40 degrees C invitro and in ovo led to 20 and 23% increases in heart rate, respectively, and a significant decrease in amplitude of Ca2+ transients (atrium -35%, ventricle -38%). We observed a wide spectrum of arrhythmias invitro, of which the most common was atrioventricular (AV) block (57%). There was variability of AV block locations. Pacing experiments invitro and in ovo suggested that the AV blocks were likely caused by relative tissue hypoxia and not by the tachycardia itself. ConclusionThe pacemaker and AV canal are the most temperature-sensitive segments of the embryonic heart. We suggest that the critical point for conduction is the connection of the ventricular trabecular network to the AV canal.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Physiologica
ISSN
1748-1708
e-ISSN
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Volume of the periodical
217
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
276-286
UT code for WoS article
000379972300005
EID of the result in the Scopus database
2-s2.0-84978933172