Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00466479" target="_blank" >RIV/67985823:_____/16:00466479 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s12035-015-9468-8" target="_blank" >http://dx.doi.org/10.1007/s12035-015-9468-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12035-015-9468-8" target="_blank" >10.1007/s12035-015-9468-8</a>

Result language
angličtina
Original language name
Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum
Original language description
Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D-1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from na < ve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D-1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)