MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00469308" target="_blank" >RIV/67985823:_____/16:00469308 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/16:00469308
Result on the web
<a href="https://worldwide.espacenet.com/publicationDetails/biblio?CC=RU&NR=2585216C2&KC=C2&FT=D&ND=4&date=20160527&DB=&loc" target="_blank" >https://worldwide.espacenet.com/publicationDetails/biblio?CC=RU&NR=2585216C2&KC=C2&FT=D&ND=4&date=20160527&DB=&loc</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL
Original language description
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
RU2585216
Publisher
RU001 -
Publisher name
Federal Service for Intellectual Property, Patents and Trademarks (ROSPATENT)
Place of publication
Moscow
Publication country
RU - RUSSIAN FEDERATION
Date of acceptance
May 27, 2016
Owner name
Institut Pasteur (FR)- Fyziologický ústav AV ČR,v. v. i.- Mikrobiologický ústav AV ČR, v. v. i.
Method of use
B - Výsledek je využíván orgány státní nebo veřejné správy
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence