Circadian dynamics of high frequency oscillations in patients with epilepsy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00472661" target="_blank" >RIV/67985823:_____/16:00472661 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/16:00243009 RIV/00216208:11130/16:10335794 RIV/00064203:_____/16:10335794
Result on the web
<a href="http://dx.doi.org/10.5220/0005827602840289" target="_blank" >http://dx.doi.org/10.5220/0005827602840289</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5220/0005827602840289" target="_blank" >10.5220/0005827602840289</a>

Result language
angličtina
Original language name
Circadian dynamics of high frequency oscillations in patients with epilepsy
Original language description
High frequency oscillations (HFOs) are novel biomarker of epileptogenic tissue. HFOs are currently used to localize the seizure generating areas of the brain, delineate the resection and to monitor the disease activity. It is well established that spatiotemporal dynamics of HFOs can be modified by sleep-wake cycle. In this study we aimed to evaluate in detail circadian and ultradian changes in HFO dynamics using techniques of automatic HFO detection. For this purpose we have developed and implemented novel algorithm to automatic detection and analysis of HFOs in long-term intracranial recordings of six patients. In 5/6 patients HFO rates significantly increased during NREM sleep. The largest NREM related increase in HFO rates were observed in brain areas which spatially overlapped with seizure onset zone. Analysis of long-term recording revealed existence of ultradian changes in HFO dynamics. This study demonstrated reliability of automatic HFO detection in the analysis of long-term intracranial recordings in humans. Obtained results can foster practical implementation of automatic HFO detecting algorithms into presurgical examination, dramatically decrease human labour and increase the information yield of HFOs.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOSIGNALS
ISBN
978-989758170-0
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
284-289
Publisher name
SciTePress
Place of publication
Rome
Event location
Rome
Event date
Feb 21, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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