Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00474132" target="_blank" >RIV/67985823:_____/17:00474132 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10361488

Result on the web

<a href="http://dx.doi.org/10.1007/s00418-016-1488-6" target="_blank" >http://dx.doi.org/10.1007/s00418-016-1488-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00418-016-1488-6" target="_blank" >10.1007/s00418-016-1488-6</a>

Result language

angličtina

Original language name

Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake

Original language description

We aimed to study the impact of altered thyroid status on myocardial expression of electrical coupling protein connexin-43 (Cx43), the susceptibility of rats to ventricular fibrillation (VF) and the effects of antioxidant-rich red palm oil (RPO). We found that function of the heart was partially normalized by RPO intake, which also enhanced myocardial Cx43 and PKC-epsilon expression as well as increased VF threshold in hyperthyroid male rats. From the results obtained we conclude that there is an inverse relationship between myocardial expression of Cx43, including its functional phosphorylated forms, and susceptibility of male rat hearts to VF in condition of altered thyroid status. RPO intake partly ameliorated adverse changes caused by excess of thyroid hormones.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Histochemistry and Cell Biology

ISSN

0948-6143

e-ISSN

—

Volume of the periodical

147

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

63-73

UT code for WoS article

000392063000007

EID of the result in the Scopus database

2-s2.0-84986253889