Exploring the contribution of spatial navigation to cognitive functioning in older adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00477002" target="_blank" >RIV/67985823:_____/17:00477002 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/17:00066280 RIV/00216208:11130/17:10373849 RIV/00064203:_____/17:10373849

Result on the web

<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.003" target="_blank" >http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.003" target="_blank" >10.1016/j.neurobiolaging.2016.12.003</a>

Result language

angličtina

Original language name

Exploring the contribution of spatial navigation to cognitive functioning in older adults

Original language description

Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested whether SN performance, self-centered (egocentric) and world-centered (allocentric), was distinguishable from performance on established cognitive functions-verbal and nonverbal memory, executive and visuospatial function, attention/working memory, and language function. 108 older adults ( 53 cognitively normal [CN] and 55 with amnestic mild cognitive impairment [aMCI]) underwent neuropsychological examination and real-space navigation testing. Subset (n = 63) had automated hippocampal volumetry. In a factor analysis, allocentric and egocentric navigation tasks loaded highly onto the same factor with low loadings on other factors comprising other cognitive functions. In linear regression, performance on other cognitive functions was not, or was only marginally, associated with spatial navigation performance in CN or aMCI groups. After adjustment for age, gender, and education, right hippocampal volume explained 26% of the variance in allocentric navigation in aMCI group. In conclusion, spatial navigation, a known cognitive marker of early AD, may be distinguished from other cognitive functions. Therefore, its assessment along with other major cognitive functions may be highly beneficial in terms of obtaining a comprehensive neuropsychological profile.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurobiology of Aging

ISSN

0197-4580

e-ISSN

—

Volume of the periodical

51

Issue of the periodical within the volume

Mar

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

67-70

UT code for WoS article

000397168600007

EID of the result in the Scopus database

2-s2.0-85007460070