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Plant and yeast cornichon possess a conserved acidic motif required for correct targeting of plasma membrane cargos

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00477231" target="_blank" >RIV/67985823:_____/17:00477231 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bbamcr.2017.07.004" target="_blank" >http://dx.doi.org/10.1016/j.bbamcr.2017.07.004</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbamcr.2017.07.004" target="_blank" >10.1016/j.bbamcr.2017.07.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plant and yeast cornichon possess a conserved acidic motif required for correct targeting of plasma membrane cargos

  • Original language description

    The export of membrane proteins along the secretory pathway is initiated at the endoplasmic reticulum after proteins are folded and packaged inside this organelle by their recruiting into the coat complex COPII vesicles. It is proposed that cargo receptors are required for the correct transport of proteins to its target membrane, however, little is known about ER export signals for cargo receptors. Erv14/Comichon belong to a well conserved protein family in Eukaryotes, and have been proposed to function as cargo receptors for many trans membrane proteins. Amino acid sequence alignment showed the presence of a conserved acidic motif in the C terminal in homologues from plants and yeast. Here, we demonstrate that mutation of the C-terminal acidic motif from ScErv14 or OsCNIH1, did not alter the localization of these cargo receptors, however it modified the proper targeting of the plasma membrane transporters Nhalp, Pdrl2p and Qdr2p. Our results suggest that mistargeting of these plasma membrane proteins is a consequence of a weaker interaction between the cargo receptor and cargo proteins caused by the mutation of the C-terminal acidic motif.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimica Et Biophysica Acta-Molecular Cell Research

  • ISSN

    0167-4889

  • e-ISSN

  • Volume of the periodical

    1864

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    1809-1818

  • UT code for WoS article

    000411168100024

  • EID of the result in the Scopus database

    2-s2.0-85025624436