Plant and yeast cornichon possess a conserved acidic motif required for correct targeting of plasma membrane cargos
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00477231" target="_blank" >RIV/67985823:_____/17:00477231 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbamcr.2017.07.004" target="_blank" >http://dx.doi.org/10.1016/j.bbamcr.2017.07.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbamcr.2017.07.004" target="_blank" >10.1016/j.bbamcr.2017.07.004</a>
Alternative languages
Result language
angličtina
Original language name
Plant and yeast cornichon possess a conserved acidic motif required for correct targeting of plasma membrane cargos
Original language description
The export of membrane proteins along the secretory pathway is initiated at the endoplasmic reticulum after proteins are folded and packaged inside this organelle by their recruiting into the coat complex COPII vesicles. It is proposed that cargo receptors are required for the correct transport of proteins to its target membrane, however, little is known about ER export signals for cargo receptors. Erv14/Comichon belong to a well conserved protein family in Eukaryotes, and have been proposed to function as cargo receptors for many trans membrane proteins. Amino acid sequence alignment showed the presence of a conserved acidic motif in the C terminal in homologues from plants and yeast. Here, we demonstrate that mutation of the C-terminal acidic motif from ScErv14 or OsCNIH1, did not alter the localization of these cargo receptors, however it modified the proper targeting of the plasma membrane transporters Nhalp, Pdrl2p and Qdr2p. Our results suggest that mistargeting of these plasma membrane proteins is a consequence of a weaker interaction between the cargo receptor and cargo proteins caused by the mutation of the C-terminal acidic motif.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica Et Biophysica Acta-Molecular Cell Research
ISSN
0167-4889
e-ISSN
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Volume of the periodical
1864
Issue of the periodical within the volume
10
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
1809-1818
UT code for WoS article
000411168100024
EID of the result in the Scopus database
2-s2.0-85025624436