Tempol and melatonin blunt antiarrhythmic effect of chronic intermittent hypoxia in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00477759" target="_blank" >RIV/67985823:_____/17:00477759 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Tempol and melatonin blunt antiarrhythmic effect of chronic intermittent hypoxia in rats
Original language description
The aim was to find out whether the antiarrhythmic protection conferred by chronic hypoxia involves reactive oxygen species (ROS). Adult male rats were adapted (24-30 exposures) to intermittent hypobaric hypoxia (IHH, 5000 m, 4 h, 5 day a week). Compared to normoxic rats, IHH significantly attenuated the burst of ROS associated with early reperfusion of isolated hearts following 15-min ischemia. The sensitivity of reperfusion arrhythmias was significantly lower in IHH hearts than in normoxic ones, in particular due to the reduced incidence of ventricular fibrillation. Tempo or melatonin given before ischemia decreased reperfusion arrhythmias in the normoxic group, but completely abolished the antiarrhythmic protection in IHH hearts. However, the effect of IHH still persisted in the hearts treated with melatonin only at reperfusion. These results suggest that IHH decreases cardiac susceptibility to reperfusion-induced ventricular arrhythmias via ROS-dependent mechanism during the ischemic period and limitation of oxidative stress at reflow.
Czech name
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Czech description
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Project
<a href="/en/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interaction between sustained forms of cardioprotection induced by adaptation to chronic hypoxia and regular exercise training.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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