Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00479718" target="_blank" >RIV/67985823:_____/17:00479718 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1139/cjpp-2017-0200" target="_blank" >http://dx.doi.org/10.1139/cjpp-2017-0200</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1139/cjpp-2017-0200" target="_blank" >10.1139/cjpp-2017-0200</a>

Result language

angličtina

Original language name

Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Original language description

Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing “remote” PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Canadian Journal of Physiology and Pharmacology

ISSN

0008-4212

e-ISSN

—

Volume of the periodical

95

Issue of the periodical within the volume

10

Country of publishing house

CA - CANADA

Number of pages

9

Pages from-to

1204-1212

UT code for WoS article

000411898100016

EID of the result in the Scopus database

2-s2.0-85030123291