Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00482662" target="_blank" >RIV/67985823:_____/17:00482662 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/17:00000313 RIV/00216208:11110/17:10360262

Result on the web

<a href="http://dx.doi.org/10.1016/j.jocn.2017.01.022" target="_blank" >http://dx.doi.org/10.1016/j.jocn.2017.01.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jocn.2017.01.022" target="_blank" >10.1016/j.jocn.2017.01.022</a>

Result language

angličtina

Original language name

Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection

Original language description

A pineal cyst is a benign affection of the human pineal gland on the borderline between pathology and normality. Only a small percentage of patients present with symptoms and a surgical treatment is indicated in highly selected cases. A melatonin secretion in patients with a pineal cyst before and after a pineal cyst resection has not been studied yet and the effect of surgery on human metabolism is unknown. The present study examined melatonin, cortisol and blood glucose secretion profiles perioperatively in a surgical group of 4 patients. The control group was represented by 3 asymptomatic patients with a pineal cyst. For each patient, 24-h circadian secretion curves of melatonin, cortisol and glycemia were acquired. An analysis of melatonin profiles showed an expected diurnal pattern with the night peak in patients before the surgery and in the control group. In contrast, melatonin levels in patients after the surgery were at their minimum throughout the whole 24-h period. The cortisol secretion was substantially increased in patients after the surgery. Blood glucose sampling showed no statistically significant differences. Clinical results demonstrated statistically significant headache relief measured by Visual Analogue Scale in patients after the surgery. Despite the small number of examined patients, we can conclude that patients with a pineal cyst preserved the physiological secretion of the hormone melatonin while patients who underwent the pineal cyst resection experienced a loss of endogenous pineal melatonin production, which equated with pinealectomy. Surprisingly, cortisol secretion substantially increased in patients after the surgery

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Neuroscience

ISSN

0967-5868

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

May 2017

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

155-163

UT code for WoS article

000399958200038

EID of the result in the Scopus database

2-s2.0-85011976676