Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00485880" target="_blank" >RIV/67985823:_____/17:00485880 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/17:00317716 RIV/00216208:11130/17:10373394 RIV/00064203:_____/17:10373394
Result on the web
<a href="http://dx.doi.org/10.3389/fneur.2017.00687" target="_blank" >http://dx.doi.org/10.3389/fneur.2017.00687</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fneur.2017.00687" target="_blank" >10.3389/fneur.2017.00687</a>
Alternative languages
Result language
angličtina
Original language name
Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate
Original language description
Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Neurology
ISSN
1664-2295
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
Dec 21
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
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UT code for WoS article
000418671200001
EID of the result in the Scopus database
2-s2.0-85039044485