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Structural aspects of protein kinase ASK1 regulation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00487591" target="_blank" >RIV/67985823:_____/17:00487591 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/17:10372344

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.jbior.2017.10.002" target="_blank" >http://dx.doi.org/10.1016/j.jbior.2017.10.002</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jbior.2017.10.002" target="_blank" >10.1016/j.jbior.2017.10.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural aspects of protein kinase ASK1 regulation

  • Original language description

    Apoptosis signal-regulating kinase 1 (ASK1, also known as MAP3K5), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, activates the p38 mitogen-activated protein kinase and the c-Jun N-terminal kinase (JNK) signaling cascades in response to various stressors. ASK1 activity is tightly regulated through phosphorylation and interaction with various binding partners. However, the mechanistic details underlying the ASK1 regulation are still not fully understood. This review focuses on recent advances in structural studies of protein kinase ASK1 and on the insights they provide into its mechanism of regulation. In addition, we also discuss protein–protein interactions between ASK1 and its binding partners thioredoxin (TRX) and 14-3-3 protein.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advances in Biological Regulation

  • ISSN

    2212-4926

  • e-ISSN

  • Volume of the periodical

    66

  • Issue of the periodical within the volume

    1 Dec

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    6

  • Pages from-to

    31-36

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85039855438