Effect of ageing on the myosin heavy chain composition of the human sternocleidomastoid muscle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00490239" target="_blank" >RIV/67985823:_____/18:00490239 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.aanat.2017.12.001" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2017.12.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aanat.2017.12.001" target="_blank" >10.1016/j.aanat.2017.12.001</a>
Alternative languages
Result language
angličtina
Original language name
Effect of ageing on the myosin heavy chain composition of the human sternocleidomastoid muscle
Original language description
The myosin heavy chain (MyHC) composition of ageing limb muscles is transformed into a slower phenotype and expresses fast-twitch fibre type atrophy, presumably due to age-related motor unit remodelling and a change in the patterns of physical activity. It is not known if ageing affects the sternocleidomastoid muscle (SCM) in a similar way. The goal of the study was to analyze the MyHC composition and the size of muscle fibres in the ageing SCM by immunohistochemical methods and quantitative analysis and stereology using our own software for morphometry. We hypothesize that with ageing the MyHC composition of SCM transforms similarly as in ageing limb muscles, but the size of the muscle fibres is less effected as in limb muscles. The study was performed on the autopsy samples of the SCM in 12 older males. The results were compared with those published in our previous study on 15 young adult males. An ageing SCM transforms into a slower MyHC profile: the percentage of slow-twitch fibres is enhanced (numerical proportion 44.6 vs. 31.5%, P < 0.05, area proportion 57.2 vs. 38.4%, P < 0.05). The share of hybrid 2a/2x fibres is diminished (numerical proportion 14.1 vs. 26.8%, P < 0.05), the area proportion of all fast twitch fibres expressing MyHC-2a and 2x is smaller (50.6 vs. 63.5%, P < 0.05), and the area proportion of fibres expressing the fastest myosin isoform MyHC-2x is smaller too (19.0 vs. 34.5%, P < 0.05). The slower phenotype with the preferential reduction of the fibres expressing the fastest MyHC-2x provide circumstantial evidence for: (i) more fast-twitch than slow-twitch motor units being lost, and (ii) reinnervation by the surviving motor units. There appears to be no significant influence on muscle fibre size, which is congruent with relatively unchanged SCM activity during life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annals of Anatomy-Anatomischer Anzeiger
ISSN
0940-9602
e-ISSN
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Volume of the periodical
216
Issue of the periodical within the volume
March
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
95-99
UT code for WoS article
000430645200012
EID of the result in the Scopus database
2-s2.0-85040020506