Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00490334" target="_blank" >RIV/67985823:_____/18:00490334 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/1873-3468.12991" target="_blank" >http://dx.doi.org/10.1002/1873-3468.12991</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/1873-3468.12991" target="_blank" >10.1002/1873-3468.12991</a>
Alternative languages
Result language
angličtina
Original language name
Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1)
Original language description
ATPase Inhibitory factor 1 (IF1) is an endogenous regulator of mitochondrial ATP synthase, which is involved in cellular metabolism. Although great progress has been made, biological roles of IF1 and molecular mechanisms of its action are still to be elucidated. Here, we show that IF1 is present in pancreatic beta-cells, bound to the ATP synthase also under normal physiological conditions. IF1 silencing in model pancreatic beta-cells (INS-1E) increases insulin secretion over a range of glucose concentrations. The left-shifted dose-response curve reveals excessive insulin secretion even under low glucose, corresponding to fasting conditions. A parallel increase in cellular respiration and ATP levels is observed. To conclude, our results indicate that IF1 is a negative regulator of insulin secretion involved in pancreatic beta-cell glucose sensing.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
1873-3468
e-ISSN
—
Volume of the periodical
592
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
999-1009
UT code for WoS article
000428400000014
EID of the result in the Scopus database
2-s2.0-85042323102