The Role of Vascular Smooth Muscle Cells in the Physiology and Pathophysiology of Blood Vessels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00499708" target="_blank" >RIV/67985823:_____/18:00499708 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/intechopen.77115" target="_blank" >http://dx.doi.org/10.5772/intechopen.77115</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/intechopen.77115" target="_blank" >10.5772/intechopen.77115</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Vascular Smooth Muscle Cells in the Physiology and Pathophysiology of Blood Vessels
Original language description
Vascular smooth muscle cells (VSMCs) play important roles not only in the physiological functions of the blood vessels, such as vasoconstriction, vasodilatation and extracellular matrix production, but also in the pathogenesis of vascular diseases, particularly atherosclerosis and hypertension. VSMCs are mostly of mesodermal origin, although some are of neuroectodermal origin, for example, VSMCs present in the aorta and in blood vessels arising from the aortic arch. VSMCs of neuroectodermal origin are implicated in defects of cardiovascular morphogenesis, such as bicuspid aortic valve, coarctation of the aorta, patent ductus arteriosus and tetralogy of Fallot. The origin, location in the vascular tree, gender, species, strain and age influence the phenotype of VSMCs and their propensity to migration and growth. In a healthy adult organism, VSMCs have a quiescent and differentiated contractile phenotype characterized by early markers (e.g., SM alpha-actin, SM22-alpha), intermediate markers (h-caldesmon, calponin) and late markers (SM myosins, smoothelin) of VSMC differentiation. However, after blood vessel injury, surgery or explantation in vitro, VSMCs undergo a phenotypic modulation to synthetic phenotype, which endows them with high activity in migration, growth and proteosynthesis. These features can lead to stenosis or to obliteration of the vascular lumen and impaired blood supply to various tissues and organs.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Muscle Cell and Tissue : Current Status of Research Field
ISBN
978-1-78984-006-3
Number of pages of the result
29
Pages from-to
229-257
Number of pages of the book
357
Publisher name
IntechOpen
Place of publication
London
UT code for WoS chapter
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