Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00504094" target="_blank" >RIV/67985823:_____/19:00504094 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11010-018-3463-0" target="_blank" >https://link.springer.com/article/10.1007%2Fs11010-018-3463-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-018-3463-0" target="_blank" >10.1007/s11010-018-3463-0</a>
Alternative languages
Result language
angličtina
Original language name
Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats
Original language description
We aimed to explore whether specific high-sucrose intake in older female rats affects myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) signaling, miR-1 and miR-30a expression, and susceptibility of the heart to malignant arrhythmias. Possible benefit of the supplementation with melatonin (40 mu g/ml/day) and omega-3 polyunsaturated fatty acids (Omacor, 25g/kg of rat chow) was examined as well. Results have shown that 8weeks lasting intake of 30% sucrose solution increased serum cholesterol, triglycerides, body weight, heart weight, and retroperitoneal adipose tissues. It was accompanied by downregulation of cardiac Cx43 and PKC epsilon signaling along with an upregulation of myocardial PKC and miR-30a rendering the heart prone to ventricular arrhythmias. There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. The potential impact of these findings may be considerable, and suggests that high-sucrose intake impairs myocardial signaling mediated by Cx43 and PKC contributing to increased susceptibility of the older obese female rat hearts to malignant arrhythmias.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
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Volume of the periodical
454
Issue of the periodical within the volume
1-2
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
191-202
UT code for WoS article
000461046100017
EID of the result in the Scopus database
2-s2.0-85056615215