A therapeutic dose of memantine improves the performance of rats in an active place avoidance task under the continuous dissociation of distal room and proximal arena cues

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00506193" target="_blank" >RIV/67985823:_____/19:00506193 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.nlm.2019.03.011" target="_blank" >https://doi.org/10.1016/j.nlm.2019.03.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nlm.2019.03.011" target="_blank" >10.1016/j.nlm.2019.03.011</a>

Result language

angličtina

Original language name

A therapeutic dose of memantine improves the performance of rats in an active place avoidance task under the continuous dissociation of distal room and proximal arena cues

Original language description

Memory is related to the function of N-methyl-D-aspartate (NMDA) receptors. Depending on the dose, NMDA receptor antagonists (such as memantine or MK-801) can impair memory and/or cognitive as well as procedural functions, while they also can prevent the long-term toxic effects of over-excitation of these receptors in pathophysiological processes. There is an unresolved question of whether memantine at low doses could exert an acute pro-cognitive activity. A therapeutic dose of memantine was found to improve short-term spatial memory tested in the alternation version of active place avoidance in a Carousel Maze, whereas no data are available on long-term memory in various versions of place avoidance. In an effort to reconcile this issue, rats were administered memantine (5 mg/kg) 30 min before a training session and trained in two different versions of place avoidance. A control group received saline injections. In an active place avoidance task (hereby referred to as Room + Arena -), this place was fixed to distal room cues, whereas cues from the arena were misleading. Performance thus demanded the on-going segregation of information that engages cognitive coordination. Following the Room + Arena - training, rats were trained in another place avoidance task (hereby referred to as Arena +), which requires focusing on substratal and idiothetic cues from the arena. In this version, a to-be avoided sector rotated along with the arena in darkness that hid the extramaze cues. The rats given memantine avoided better than the control rats in the Room + Arena - task. In the Arena + task, both groups had problems with acquiring the task. Subsequently, memantine was withdrawn and both groups relearned Room + Arena - avoidance with a new sector position. In this task, no effect of groups was seen. In conclusion, memantine at a therapeutic dose improved performance in a task that required the segregation of spatial stimuli into coherent subsets.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurobiology of Learning and Memory

ISSN

1074-7427

e-ISSN

—

Volume of the periodical

162

Issue of the periodical within the volume

Jul

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

59-66

UT code for WoS article

000471982500007

EID of the result in the Scopus database

2-s2.0-85066232093