A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00509156" target="_blank" >RIV/67985823:_____/19:00509156 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21220/19:00332035

Result on the web

<a href="https://doi.org/10.1016/j.diamond.2019.107456" target="_blank" >https://doi.org/10.1016/j.diamond.2019.107456</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diamond.2019.107456" target="_blank" >10.1016/j.diamond.2019.107456</a>

Result language

angličtina

Original language name

A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

Original language description

Diamond-like carbon (DLC) coatings exhibit excellent mechanical properties and improve the smoothness and the wear characteristic of the metallic component of total joint replacements. Although DLC is considered to be highly biocompatible, the effect of implant wear debris must be carefully analyzed. Simulated loading can help to mimic the wear of the implant in the human body over time. The purpose of the study presented here is to observe the wear of trapeziometacarpal (TMC) total joint arthroplasty implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer (Ti/Ti-C:H), and to analyze the potential cytotoxicity of the wear particles generated by simulated loading. No visible wear or delamination of the DLC coating was observed after 3 million cycles of increasing loading force up to 2.5 kN. Accordingly, no correlation was observed between increasing number of loading cycles (with increasing loading force) and decreasing proliferation of human osteoblast-like cells incubated in the wear suspension. We can therefore conclude that no cytotoxic wear debris was formed during the simulated loading of TMC total joint replacement implant composed of DLC-coated Co-Cr-Mo alloy with Ti/Ti-C:H gradient interlayer.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diamond and Related Materials

ISSN

0925-9635

e-ISSN

—

Volume of the periodical

97

Issue of the periodical within the volume

Aug

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

UNSP 107456

UT code for WoS article

000486134300030

EID of the result in the Scopus database

2-s2.0-85067806655