Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in updates home parenteral nutrition patients: a crossover study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00520626" target="_blank" >RIV/67985823:_____/19:00520626 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.nutres.2019.10.004" target="_blank" >https://doi.org/10.1016/j.nutres.2019.10.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nutres.2019.10.004" target="_blank" >10.1016/j.nutres.2019.10.004</a>

Result language

angličtina

Original language name

Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in updates home parenteral nutrition patients: a crossover study

Original language description

Long-chain n-3 polyunsaturated fatty acids modulate immune cell functions. The primary objective of this study was to evaluate the impact of different lipid emulsions (LEs) with supplemented doses of fish oil (FO) on serum cytokine concentration and in vitro cytokine production in patients with intestinal failure on home parenteral nutrition (HPNPs). We hypothesized that FO supplementation would diminish lipopolysaccharide (LPS)-stimulated cytokine production. Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. After this cycle, the patients were randomized to subsequently receive 1 cycle with Lipoplus and 1 cycle with ClinOleic for 6 weeks or vice versa plus 4 weeks of added Omegaven after each cycle in a crossover design. Comparison of the baseline LE regimens showed lower LPS-stimulated production of IL-1 beta in the HPNPs on Lipoplus than on the Smoflipid and ClinOleic regimens, as well as lower IL-8 compared to the Smoflipid regimen. Omegaven reduced IL-8 concentration in serum under the Lipoplus regimen and diminished LPS-stimulated production of IL-1 beta under the Smoflipid and ClinOleic. IL-6 and TNF-alpha production was depressed only in those on Smoflipid. Irrespective of the LE used, the HPNPs compared to the healthy controls showed higher IL-6, IL-8, and TNF-alpha concentrations in serum and LPS-stimulated production of IL-6 as well as lower n-6/n-3 long-chain polyunsaturated fatty acids in the erythrocyte phospholipids. LPS- stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. In conclusion, FO-supplemented parenteral nutrition suppresses in vitro cytokine production

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition Research

ISSN

0271-5317

e-ISSN

—

Volume of the periodical

72

Issue of the periodical within the volume

Dec

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

70-79

UT code for WoS article

000505272700006

EID of the result in the Scopus database

2-s2.0-85076218799