All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Maternal diet, rather than obesity itself, has a main influence on milk triacylglycerol profile in dietary obese rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524169" target="_blank" >RIV/67985823:_____/20:00524169 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1016/j.bbalip.2019.158556" target="_blank" >https://doi.org/10.1016/j.bbalip.2019.158556</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbalip.2019.158556" target="_blank" >10.1016/j.bbalip.2019.158556</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Maternal diet, rather than obesity itself, has a main influence on milk triacylglycerol profile in dietary obese rats

  • Original language description

    Triacylglycerols (TG) in milk derive from different sources, and their composition may be influenced by both maternal diet and obesity. We used two rat models to ascertain potential changes in TG composition in milk associated to maternal intake of an obesogenic diet during lactation and to distinguish them from the effects attributable to maternal adiposity. Milk samples were obtained from dams fed a cafeteria diet during lactation (CAF) and from dams made obese by cafeteria diet feeding, with dietary normalization before gestation (PCaf). Levels of specific TG species in milk collected at different time points of lactation were determined by shotgun lipidomics. CAF and PCaf dams presented a greater adiposity than their respective controls. The principal component analysis of TG peaks showed a clear separation between milk from CAF dams and milk from control and Pcaf dams, already evident at 5 days of lactation. Milk from CAF dams was enriched with TG species with greater number of carbons and double bonds and reduced in TG with lower number of carbons. TG composition of milk from Pcaf dams was similar to controls, although specific differences were observed at day 5 of lactation. Thus, the intake of a cafeteria diet during lactation, rather than maternal adiposity, alters milk composition. This effect is avoided with dietary normalization before gestation, although the remaining fat reserves may also influence TG composition at initial stages of lactation. Therefore, normalization of maternal diet prior to pregnancy should be considered as a strategy for achieving optimal milk composition.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    <a href="/en/project/GA19-02411S" target="_blank" >GA19-02411S: Role of adipose tissue metabolism in propensity to obesity: UCP1-independent mechanisms</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids

  • ISSN

    1388-1981

  • e-ISSN

  • Volume of the periodical

    1865

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    158556

  • UT code for WoS article

    000509816500017

  • EID of the result in the Scopus database

    2-s2.0-85074798150