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Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524170" target="_blank" >RIV/67985823:_____/20:00524170 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/20:43919238 RIV/00064173:_____/20:N0000038

  • Result on the web

    <a href="https://doi.org/10.1016/j.bbalip.2019.158576" target="_blank" >https://doi.org/10.1016/j.bbalip.2019.158576</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbalip.2019.158576" target="_blank" >10.1016/j.bbalip.2019.158576</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women

  • Original language description

    Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids

  • ISSN

    1388-1981

  • e-ISSN

  • Volume of the periodical

    1865

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    158576

  • UT code for WoS article

    000509816500022

  • EID of the result in the Scopus database

    2-s2.0-85075263746