Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524175" target="_blank" >RIV/67985823:_____/20:00524175 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/20:10420691 RIV/00216208:11320/20:10420691

Result on the web

<a href="https://www.mdpi.com/2073-4409/9/1/57" target="_blank" >https://www.mdpi.com/2073-4409/9/1/57</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells9010057" target="_blank" >10.3390/cells9010057</a>

Result language

angličtina

Original language name

Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

Original language description

Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an evolutionary divergence. Mouse TRPA1 was implicated in noxious cold detection but was later also identified as one of the prime noxious heat sensors. Moreover, human TRPA1, originally considered to be temperature-insensitive, turned out to act as an intrinsic bidirectional thermosensor that is capable of sensing both cold and heat. Using electrophysiology and modeling, we compare the properties of human and mouse TRPA1, and we demonstrate that both orthologues are activated by heat, and their kinetically distinct components of voltage-dependent gating are differentially modulated by heat and cold. Furthermore, we show that both orthologues can be strongly activated by cold after the concurrent application of voltage and heat. We propose an allosteric mechanism that could account for the variability in TRPA1 temperature responsiveness.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA19-03777S" target="_blank" >GA19-03777S: Molecular Basis of Thermosensitive TRP Ion Channel Regulation in Nociceptive Neurons</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

57

UT code for WoS article

000515398200057

EID of the result in the Scopus database

2-s2.0-85090250045