Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00531106" target="_blank" >RIV/67985823:_____/20:00531106 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2218-273X/10/1/93" target="_blank" >https://www.mdpi.com/2218-273X/10/1/93</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biom10010093" target="_blank" >10.3390/biom10010093</a>

Result language

angličtina

Original language name

Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Original language description

Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses, retrograde redox signaling to PGC1 alpha during exercise in skeletal muscle, redox signaling in innate immune cells, redox stimulation of insulin secretion, and other physiological situations.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA17-01813S" target="_blank" >GA17-01813S: Redox signaling by mitochondrial reactive oxygen species</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomolecules

ISSN

2218-273X

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

33

Pages from-to

93

UT code for WoS article

000514863200047

EID of the result in the Scopus database

2-s2.0-85077843514