Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00533406" target="_blank" >RIV/67985823:_____/20:00533406 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/20:10416766

Result on the web

<a href="https://doi.org/10.1016/j.mad.2020.111317" target="_blank" >https://doi.org/10.1016/j.mad.2020.111317</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mad.2020.111317" target="_blank" >10.1016/j.mad.2020.111317</a>

Result language

angličtina

Original language name

Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa

Original language description

Aging and tumorigenesis are associated with decline and disruption of circadian rhythms in many tissues and accumulating evidence indicates molecular link between circadian clock and cell cycle. The aim of this study was to investigate the effect of aging and tumorigenesis on coupling between cell cycle and circadian clock oscillators in colon, which undergoes regular rhythmicity of cell cycle and expresses peripheral circadian clock. Using healthy 14-week-old mice and 33-week-old mice with and without colorectal tumors, we showed that the 24-h expression profiles of clock genes and clock-controlled genes were mostly unaffected by aging, whereas the genes of cell cycle and cell proliferation were rhythmic in the young colons but were silenced during aging. On the other hand, tumorigenesis completely silenced or dampened the circadian rhythmicity of the clock genes but only a few genes associated with cell cycle progression and cell proliferation. These results suggest that aging impacts the colonic circadian clock moderately but markedly suppresses the rhythms of cell cycle genes and appears to uncouple the cell cycle machinery from circadian clock control. Conversely, tumorigenesis predominantly affects the rhythms of colonic circadian clocks but is not associated with uncoupling of circadian clock and cell cycle.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/GA13-08304S" target="_blank" >GA13-08304S: Role of internal time-keeping system in pathogenesis of colorectal cancer</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mechanisms of Ageing and Development

ISSN

0047-6374

e-ISSN

—

Volume of the periodical

190

Issue of the periodical within the volume

Sep

Country of publishing house

IE - IRELAND

Number of pages

10

Pages from-to

111317

UT code for WoS article

000569392800005

EID of the result in the Scopus database

2-s2.0-85089350888