Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00534241" target="_blank" >RIV/67985823:_____/20:00534241 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10417662
Result on the web
<a href="https://doi.org/10.1016/j.resp.2020.103526" target="_blank" >https://doi.org/10.1016/j.resp.2020.103526</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.resp.2020.103526" target="_blank" >10.1016/j.resp.2020.103526</a>

Result language
angličtina
Original language name
Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia
Original language description
The main aim was to find out whether long-lasting stepwise exposure to extreme hypoxia affects left ventricular (LV) geometry and systolic function. Adult male rats were exposed to intermittent hypobaric hypoxia (8 h/day) with increasing altitude in steps of 1000 m every 3 weeks up to 8000 m. While the LV cavity diastolic diameter did not change over the whole range of hypoxia, the wall thickness increased significantly at the altitude of 8000 m. LV fractional shortening ranged between 48.1 % and 50.1 % and remained unaffected even at the most severe hypoxia. At the end of experiment, haematocrit reached 83 %, mean systemic arterial pressure 120 % and relative LV weight 154 % of normoxic values while RV systolic pressure and relative RV weight doubled. Myocyte hypertrophy and myocardial fibrosis were more pronounced in RV than in LV. In conclusion, LV systolic function was preserved after chronic stepwise exposure of rats to extreme intermittent hypoxia despite moderate concentric hypertrophy and myocardial remodelling.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30105 - Physiology (including cytology)

Project
<a href="/en/project/GJ19-04790Y" target="_blank" >GJ19-04790Y: Effect of perinatal hypoxia and low-protein diet on the role of RNA-demethylase FTO in the regulation of heart function and energy metabolism</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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