Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00538469" target="_blank" >RIV/67985823:_____/20:00538469 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10422718
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/2020/69_S379.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2020/69_S379.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934595" target="_blank" >10.33549/physiolres.934595</a>
Alternative languages
Result language
angličtina
Original language name
Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities
Original language description
Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation due to asphyxia during perinatal period. It affects approximately 3-12 children per 1000 live births and cause death of 1 million neonates worldwide per year. Besides, motor disabilities, seizures, impaired muscle tone and epilepsy are few of the consequences of hypoxic-ischemic encephalopathy. Despite an extensive research effort regarding various treatment strategies, therapeutic hypothermia with intensive care unit supportive treatment remains the only approved method for neonates who have suffered from moderate to severe hypoxicischemic encephalopathy. However, these protocols are only partially effective given that many infants still suffer from severe brain damage. Thus, further research to systematically test promising neuroprotective treatments in combination with hypothermia is essential. In this review, we discussed the pathophysiology of hypoxic-ischemic encephalopathy and delved into different promising treatment modalities, such as melatonin and erythropoietin. However, preclinical studies and clinical trials are still needed to further elucidate the mechanisms of action of these modalities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
Suppl.3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
23
Pages from-to
"S379"-"S401"
UT code for WoS article
000610191500004
EID of the result in the Scopus database
2-s2.0-85100228214