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Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00538469" target="_blank" >RIV/67985823:_____/20:00538469 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/20:10422718

  • Result on the web

    <a href="http://www.biomed.cas.cz/physiolres/pdf/2020/69_S379.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2020/69_S379.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.934595" target="_blank" >10.33549/physiolres.934595</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities

  • Original language description

    Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation due to asphyxia during perinatal period. It affects approximately 3-12 children per 1000 live births and cause death of 1 million neonates worldwide per year. Besides, motor disabilities, seizures, impaired muscle tone and epilepsy are few of the consequences of hypoxic-ischemic encephalopathy. Despite an extensive research effort regarding various treatment strategies, therapeutic hypothermia with intensive care unit supportive treatment remains the only approved method for neonates who have suffered from moderate to severe hypoxicischemic encephalopathy. However, these protocols are only partially effective given that many infants still suffer from severe brain damage. Thus, further research to systematically test promising neuroprotective treatments in combination with hypothermia is essential. In this review, we discussed the pathophysiology of hypoxic-ischemic encephalopathy and delved into different promising treatment modalities, such as melatonin and erythropoietin. However, preclinical studies and clinical trials are still needed to further elucidate the mechanisms of action of these modalities.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    69

  • Issue of the periodical within the volume

    Suppl.3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    23

  • Pages from-to

    "S379"-"S401"

  • UT code for WoS article

    000610191500004

  • EID of the result in the Scopus database

    2-s2.0-85100228214