Odontoblast TRPC5 channels signal cold pain in teeth
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541625" target="_blank" >RIV/67985823:_____/21:00541625 - isvavai.cz</a>
Result on the web
<a href="https://advances.sciencemag.org/content/7/13/eabf5567" target="_blank" >https://advances.sciencemag.org/content/7/13/eabf5567</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abf5567" target="_blank" >10.1126/sciadv.abf5567</a>
Alternative languages
Result language
angličtina
Original language name
Odontoblast TRPC5 channels signal cold pain in teeth
Original language description
Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5’s relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
7
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
eabf5567
UT code for WoS article
000633443600034
EID of the result in the Scopus database
2-s2.0-85103532321